agentic AI
An approach to AI systems where agents perform tasks autonomously with tools and browser interaction. The newsletter frames 2026 as a year focused less on novelty and more on trust in deployed agentic systems.
Key Highlights
- Agentic AI describes systems that can autonomously complete multi-step tasks using tools, APIs, and browser interaction.
- The 2026 conversation shifts from whether agents work to whether users can trust them in production.
- Infrastructure partnerships like NVIDIA and Google Cloud signal that agentic AI depends on robust execution stacks, not just foundation models.
- Medable’s use of agentic AI in clinical operations shows how the concept is moving into regulated, outcome-driven workflows.
- For AI PMs, the key product challenge is balancing autonomy with oversight, safety, and measurable business value.
Agentic AI
Overview
Agentic AI refers to AI systems designed to act with a degree of autonomy to complete multi-step tasks, often by combining reasoning, memory, tool use, API calls, and browser interaction. Rather than only generating text or recommendations, agentic systems can take actions such as navigating interfaces, retrieving information, executing workflows, and coordinating across software environments to achieve an outcome.For AI Product Managers, agentic AI matters because it shifts product design from single-turn model interactions to end-to-end task completion. This raises the bar on reliability, trust, observability, safety, and human oversight. In the newsletter coverage, the framing evolves from technical capability and infrastructure readiness toward a more mature question: not whether agents can be deployed, but whether users and organizations can trust them in production for consequential workflows.
Key Developments
- 2026-01-04: Pawel Huryn described a narrative shift in agentic AI: 2025 was centered on agent reliability, while 2026 would be about earning trust. The point was that the market narrative lagged behind real deployments, suggesting that operational confidence had become the next strategic challenge.
- 2026-03-17: NVIDIA expanded its partnership with Google Cloud to co-engineer infrastructure for the next generation of agentic AI, signaling that large-scale agent deployment depends not just on models, but on cloud, compute, orchestration, and systems engineering.
- 2026-03-23: Teresa Torres highlighted Medable’s move from e-consent and electronic assessments toward agentic AI in clinical operations, showing how agents are being positioned to reduce friction in complex, regulated workflows such as drug development and patient access.
Relevance to AI PMs
1. Design for trust, not just task success AI PMs need to define product requirements beyond raw completion rate: approval checkpoints, fallback behavior, action logs, explainability, user controls, and escalation paths all become core parts of the experience when agents act autonomously.2. Evaluate the full execution stack
Shipping agentic AI requires more than model selection. PMs must assess browser automation, tool permissions, workflow orchestration, monitoring, latency, error recovery, and infrastructure dependencies to ensure the system performs reliably in real environments.
3. Target high-friction workflows with measurable ROI
The best early opportunities are repetitive, multi-step tasks with clear success criteria, such as customer operations, internal tooling, or regulated process support. PMs should prioritize use cases where autonomy reduces manual effort while still allowing structured oversight.
Related
- Medable: An example of a company applying agentic AI to clinical operations, illustrating its use in regulated, high-stakes domains.
- Teresa Torres: Highlighted Medable’s strategic shift, connecting agentic AI to product discovery and workflow redesign.
- NVIDIA: Represents the infrastructure and compute layer required to power production-grade agentic systems.
- Google Cloud: Connected through infrastructure partnership work that supports large-scale agent deployment.
- AI Agents / Agents: Closely related umbrella terms; agentic AI describes the broader approach and system design philosophy behind autonomous agents.
- Browser Automation: A key capability in many agentic systems, enabling agents to interact with web interfaces and complete real tasks.
- OpenAI Codex: Relevant as a tool-oriented AI system associated with autonomous software and workflow execution patterns.
- Vibe-coding: Related through the broader shift toward AI-assisted creation and execution, though vibe-coding is more about generation flow than autonomous action.
- Paweł Huryn: Framed the market transition from focusing on reliability to focusing on trust in deployed agentic systems.
Newsletter Mentions (3)
“Teresa Torres highlights Medable’s shift from e-consent and electronic assessments to agentic AI, reimagining clinical operations to accelerate the over-10-year drug development cycle and overcome patient access barriers.”
#9 𝕏 Teresa Torres highlights Medable’s shift from e-consent and electronic assessments to agentic AI, reimagining clinical operations to accelerate the over-10-year drug development cycle and overcome patient access barriers.
“#5 𝕏 NVIDIA AI has expanded its partnership with Google Cloud to co-engineer the core infrastructure foundation needed to power the next generation of agentic AI.”
Today's top 25 insights for PM Builders, ranked by relevance from Blogs, X, YouTube, and LinkedIn. #5 𝕏 NVIDIA AI has expanded its partnership with Google Cloud to co-engineer the core infrastructure foundation needed to power the next generation of agentic AI.
“Agentic AI narrative shift : Pawel Huryn explained that 2025 focused on agent reliability while 2026 is about earning trust , noting how the "agentic AI" narrative trailed actual deployments.”
AI Industry Developments & News Lex Fridman's technical AI podcast : Lex Fridman announced a long-form, super-technical podcast covering LLM training architectures, robotics, compute, business, geopolitics and more, inviting community topic suggestions. Open collaboration as a bull signal : Guillermo Rauch noted that a Google engineer praising other labs' tools is a bull signal , urging companies to experiment broadly rather than remain locked into a single approach. Agentic AI narrative shift : Pawel Huryn explained that 2025 focused on agent reliability while 2026 is about earning trust , noting how the "agentic AI" narrative trailed actual deployments. From LinkedIn • Deeper Insights AI Tools & Applications Automating customer service with Claude Code for Chrome : In a real-world demo, Carl Vellotti shows how the newly released Claude Code Chrome extension can autonomously navigate web pages, take screenshots, and interact with elements to resolve a refund dispute—highlighting the potential for AI agents to handle routine tasks end to end.
Related
Product discovery and AI product workflow voice mentioned as releasing a new plugin. Relevant to AI PMs for tooling that supports product workflows.
NVIDIA is promoting a CES panel on AI-native enterprise systems. For AI PMs, it reflects interest in end-to-end enterprise AI architecture.
Autonomous or semi-autonomous systems used here in sales and coding workflows. The newsletter highlights their role in replacing human SDR tasks and orchestrating complex tasks.
A coding style where developers use AI to generate and iterate on code through conversational workflows. The newsletter frames it as reshaping developer workflows and increasing the importance of context management.
Product management writer known for tactical PM advice. Here he warns that coding agents need security and performance audits.
OpenAI's code-focused assistant used for debugging and diagnosing AI-generated builds.
Google’s cloud platform used here for project-scoped access control around Gemini API keys. For PMs, it reflects enterprise-grade collaboration and permissioning.
A healthcare company mentioned as the maker of Agent Studio for clinical and compliance-heavy workflows.
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